BEIJING (WSYX) — Scientists have shown that genetically modified human stem cells can delay aging symptoms in monkeys, potentially paving the way for treatments aimed at age-related decline in humans.
Stem Cell Therapy Cuts Aging Signs in Monkeys Without Side Effects
Over a 44-week period, researchers treated cynomolgus monkeys with senescence-resistant mesenchymal progenitor cells (SRCs) engineered with the longevity-associated FOXO3 gene. The therapy lowered indicators of cellular aging, chronic inflammation, and tissue damage, all without significant side effects.
Scientists slow aging in monkeys with engineered stem cells, study finds (Cell)
Therapy Boosts Memory, Brain, Bone, and Reproductive Health While Reversing Tissue Aging in Monkeys
Monkeys treated with the therapy exhibited better performance in memory tasks, enhanced brain structure, improved bone density, and healthier reproductive function. Further analysis revealed signs of rejuvenation in the blood and various organs, with biological “aging clocks” indicating that tissue age had been reduced by several years.
Published in Cell, the study identifies exosomes—small vesicles released by the transplanted cells—as major contributors to the observed rejuvenation. Although still in the early stages, the researchers noted that this is the first evidence showing that engineered human progenitor cells can slow systemic aging in primates, offering a promising foundation for future regenerative therapies in humans.
Read the original article on: abc6
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