Tag: Hear

  • Your Intelligence may Affect How Well you Hear in Noise

    Your Intelligence may Affect How Well you Hear in Noise

    New research shows that intelligence significantly influences how people understand speech in noisy settings. By comparing neurotypical and neurodivergent individuals, the study found that cognitive ability predicted performance in every group. The findings challenge the idea that listening problems stem solely from hearing loss, emphasizing the brain’s key role.
    Image Credits:Shutterstock

    New research shows that intelligence significantly influences how people understand speech in noisy settings. By comparing neurotypical and neurodivergent individuals, the study found that cognitive ability predicted performance in every group. The findings challenge the idea that listening problems stem solely from hearing loss, emphasizing the brain’s key role.

    Picture chatting in a noisy café—what seems like a hearing issue may actually stem from how your brain processes sound.

    Cognitive Ability Affects Speech Understanding in Noise

    A study found that cognitive ability strongly influenced speech understanding in noisy settings. Even though everyone had normal hearing, their performance differed according to their intellectual capacity.

    The link between cognitive ability and speech perception appeared across all groups,” said lead researcher Bonnie Lau, a UW assistant professor of otolaryngology–head and neck surgery.

    The study’s results were published in PLOS One.

    Small Study Links Intelligence to Noisy Listening

    Lau noted that with fewer than 50 participants, the study should be replicated with larger groups, but the results suggest intelligence influences how well people listen in noisy environments.

    To test their hypothesis, researchers included participants with autism and fetal alcohol syndrome—groups with normal hearing but known listening challenges—to widen the IQ range and enable broader comparison.

    The study included 12 autistic, 10 fetal alcohol syndrome, and 27 neurotypical participants matched by age and sex. Participants ranged in age from 13 to 47. Each underwent an audiology screening to confirm normal hearing before completing a computer-based listening task.

    Participants Tasked with Focusing on One Voice Amid Competing Speakers

    In the experiment, participants listened to a main speaker’s voice while two other voices spoke at the same time in the background. Their task was to focus on the main speaker—always male—and ignore the competing voices. Each voice gave a brief command containing a call sign, color, and number, such as “Ready, Eagle, go to green five now.

    Participants then selected the box with the correct color and number that matched the main speaker’s command as the background voices gradually increased in volume.

    Afterward, they completed standardized intelligence tests assessing verbal and nonverbal skills as well as perceptual reasoning. The researchers compared these cognitive scores with participants’ performance on the multitalker listening test.

    The data revealed a strong link between intelligence and listening performance.

    Study Finds Strong Link Between Intelligence and Speech Perception

    We observed a highly significant association between directly measured intellectual ability and multitalker speech perception,” the researchers wrote. “Intellectual ability was significantly correlated with speech perception thresholds across all three groups.

    Lau noted that effective listening in noisy environments relies on extensive brain processing.

    You must separate voices, focus on one speaker, and filter out noise,” Lau said. “Then, you need to process language—identifying phonemes, syllables, and words—while also engaging socially by smiling or nodding. All of this adds to the cognitive effort required to communicate in noisy environments.”

    Lau said the study challenges a common misconception that listening difficulties always indicate peripheral hearing loss.

    You don’t need to have hearing loss to struggle with listening in a restaurant or other noisy real-world setting,” she noted.

    Researchers said neurodivergent or lower-IQ individuals may benefit from better listening setups, like front seating or assistive devices.

    Lau carries out her research at the UW Virginia Merrill Bloedel Hearing Research Center. Her coauthors represent multiple UW departments and centers, as well as the University of Michigan’s Department of Otolaryngology–Head and Neck Surgery.


    Read the original article on: Sciencedaily

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  • Gene Therapy Trial Enables 5 Deaf Children to Hear

    Gene Therapy Trial Enables 5 Deaf Children to Hear

    A groundbreaking clinical trial utilizing gene therapy has successfully restored hearing in five children who were born deaf. Within six months, these children regained the ability to recognize speech and engage in conversations, sparking optimism for broader application in the near future.
    Five children born deaf have gained the ability to hear and recognize speech, thanks to a groundbreaking gene therapy clinical trial
    Depositphotos

    A groundbreaking clinical trial utilizing gene therapy has successfully restored hearing in five children who were born deaf. Within six months, these children regained the ability to recognize speech and engage in conversations, sparking optimism for broader application in the near future.

    The participants in the trial were afflicted with autosomal recessive deafness 9 (DFNB9), a genetic condition stemming from a mutation in the OTOF gene. This gene is responsible for producing the otoferlin protein, essential for transmitting electrical pulses from the cochlea to the brain, where they are interpreted as sound. In the absence of this protein, these signals fail to reach the brain. Due to its singular mutation nature and the absence of physical cell damage, the research team deems DFNB9 an ideal candidate for this type of gene therapy.

    Gene Therapy’s Intricate Process in Restoring Otoferlin Protein

    The gene therapy procedure entails encapsulating the OTOF gene within viral carriers, which are then injected into the inner ear fluid. Subsequently, the viruses locate cells in the cochlea, introducing the gene to enable these cells to produce the lacking otoferlin protein, thereby restoring hearing.

    Conducted in China, the study involved collaboration among researchers from Harvard Medical School, Massachusetts Eye and Ear, and Fudan University. The six participants, aged one to seven years old, all suffered from complete deafness due to DFNB9. Despite having cochlear implants, which typically help individuals recognize speech and other sounds, the implants were deactivated for this study.

    Throughout the 26-week follow-up period post-gene therapy, five out of six participants exhibited notable improvements. The three older children could comprehend and respond to speech, while two could discern it in noisy environments and engage in phone conversations. Although some of the younger children were too small for standard tests, they demonstrated responsiveness to sounds and even began uttering basic words like “mama.” The progress was gradual, with improvements evident before the initial test at the four-week mark.

    Yilai Shu’s Heartwarming Encounter with Initial Responses to Restored Hearing

    Yilai Shu, the senior author of the study, shared an anecdote: “We first found out when the parents told us: When her mother called her, she turned back. All of them are very hopeful. They were very, very excited, and all of them cried when they first found that their child can hear.”

    Regrettably, one participant did not respond to the treatment. While the precise cause remains uncertain, researchers suspect an immune reaction disrupted the viral vector. Further investigation may offer insights into overcoming this challenge.

    The researchers indicate ongoing monitoring for participants in this trial, with additional studies planned for different individuals. The team estimates that approval for the treatment in the United States might be three to five years away. Similar gene therapies have undergone testing for hearing loss attributed to genetic or age-related factors.


    Read the original article on: New Atlas

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