Biotechnology

Improving AI Intuition in the Discovery of New Medicines

Overall schematic of the main idea behind the study. Molecules compete based on chemist feedback, forming an implicit score model through neural network training. This model assigns scores to molecules, enabling their use in cheminformatics applications. Credit: Nature Communications (2023). DOI: 10.1038/s41467-023-42242-1A collaborative effort between biomedical researchers at Novartis Institutes for Biomedical Research and Microsoft Research...

Breaking Down Breast Cancer: Targeting PTPRD with Antibodies

Developed through collaboration between graduate student Zhe Qian and Cold Spring Harbor Laboratory's Antibody & Phage Display Shared Resource, the synthetic antibody RD-43 shows potential in halting the progression of breast cancer by degrading the PTPRD enzyme. Image credit: Tonks lab/Cold Spring Harbor LaboratoryAn enzyme that may help some breast cancers spread can be...

A Molecular-Based, Finite-State Device

Credit: Unsplash/CC0 Public DomainA little group of scientists at the College of Manchester has created a method for producing a molecular based, finite-state device. Their research study was released in the journal Nature.In computer science, there is a virtual tool referred to as a Turing machine, established by Alan Turing as a means to...

An Automatically Adjusting Exoskeleton that Adapts to Your Way of Walking

A close-up of the untethered exoskeleton. Credit: Stanford University.A new robotic, boot-like exoskeleton utilizes wearable sensors to adapt to each individual that wears it, marking a considerable progression for robotics. The device, explained in a study released yesterday, helps address one of the major obstacles in developing systems that aid people to walk:...

The Most Advanced AI-powered Prosthetics ‘Ever Created’

Utah Bionic Leg. Credit: University of UtahScientists from the University of Utah have created the most sophisticated AI-powered prosthetics "ever created," prompting Ottobock, the world's largest prosthetic manufacturer, to team up, launching the project internationally.https://twitter.com/UUtah/status/1578482268091211776?s=20&t=To8VYjrAITT-HDAaByZdxwThe university's Tommaso Lenzi, associate professor at the university's Department of Mechanical Engineering and director of the Bionic Engineering Lab,...

Light Accelerates Conductivity In Nature’s ‘Electric Grid’

Credit: Pixabay/CC0 Public DomainThe natural world has its own intrinsic electrical grid composed of a world web of tiny bacteria-generated nanowires in the soil and seas that "breathe" by exhaling excess electrons.In a new study, Yale College researchers found that light is an unexpected ally in fostering this electronic activity within biofilm bacteria. Revealing bacteria-produced...

New Computational Approach Creates Spatial Maps of Single-Cell Data Within Tissues

A hairpin loop from a pre-mRNA. Highlighted are the nucleobases (green) and the ribose-phosphate backbone (blue). Note that this is a single strand of RNA that folds back upon itself. Credit: Vossman/ WikipediaA new computational method created by researchers at The University of Texas MD Anderson Cancer Center successfully matches data from correspondent gene-expression...

This Biohacker Became the First Person to Edit His Own DNA

Credit: CI Photos/ShutterstockJosiah Zayner is the first individual known to have modified his personal DNA and he revealed the planet just how easy it is to do, live-streaming the process on his blog, "Science, Art, Beauty". Zayner claims this was the second time he has genetically changed himself.Utilizing CRISPR, a fairly new gene-editing method,...

Bacteria with Recording Function Capture Gut Health Status

Credit: Pixabay/CC0 Public DomainOur intestine is residence to plenty of bacteria, which help us digest food. However, just what do the microorganisms do inside the body? Which enzymes do they create, and when? And how do the bacteria metabolize health-promoting foods that aid us in minimizing disease?To obtain replies to such matters, researchers at...

Revolutionary Coating for Blood Vessels Minimizes Rejection of Transplanted Organs

Blood vessels in mouse kidneys were covered with a unique polymer, which aided in preventing the recipient mouse's body immune system from rejecting the new kidneys after a transplant. Credit: Dr. Erika SirenScientists have recently found a route to decrease organ rejection after a transplant by utilizing a unique polymer to cover blood vessels...