How Sleep Prepares Your Brain for Tomorrow

Your brain not only has to store a huge collection of past memories, but it also needs to handle new information daily—meaning it must prepare for forming new memories even as it processes existing ones.

Sleep is widely recognized as essential for memory and learning, but many of the exact processes behind it remain unclear.

Sleep has traditionally been understood as a process that looks backward—where experiences are processed and stored as memories during the nights that follow, allowing us to recall them later.

A Tool for Remembering the Past and Preparing for the Future

A new study suggests sleep helps process past memories and prepare for future ones. Beyond just consolidating existing memories, the brain appears to get ready to capture new experiences while we sleep.

Memory is a complex, multi-dimensional process that shapes our identity, and from a personal viewpoint, it can feel almost magical—something that transcends simple, separate parts.

However, it’s not magical. Engram cells are specialized neurons that store our experiences, making them retrievable later.

Previous research highlights sleep’s importance for memory function, though many physiological details remain unclear. Beyond storing memories, the brain also processes and organizes information, much of which occurs during mental rest.

Exploring Sleep’s Role in Memory Processing and Future Preparation

In the new study, researchers in Japan aimed to explore the role of sleep in memory processing, including how it helps prepare for future memorable experiences.

The researchers used an imaging system for moving mice to track both engram and non-engram cells during memory processing. This allowed them to monitor neuronal activity before, during, and after significant events the mice experienced.

This offered new insights into neuron behavior under various cognitive conditions, including during sleep before and after learning experiences.

The results revealed two simultaneous processes occurring during post-learning sleep. Engram cells that encoded a memory showed consistent reactivation patterns, crucial for memory consolidation during sleep.

The study also uncovered another intriguing group of neurons that hadn’t yet been linked to specific memories. These “engram-to-be cells,” as the researchers termed them, became more synchronized as the mice slept after learning. Eventually, these same neuron groups went on to encode new and distinct memories.

“Engram-to-be cells showed increased coactivity with engram cells during sleep, suggesting this helps form new memory networks,” says co-author Kaoru Inokuchi.

Modeling Hippocampal Activity to Reveal Engram-to-Be Cell Mechanisms

The researchers also created a neural network model to simulate hippocampal activity, aiming to better understand the underlying processes. The model indicated that synaptic depression and scaling are key to organizing engram-to-be cells. Disabling these mechanisms reduced cell organization.

The study found that engram and engram-to-be cells co-activated during post-learning sleep, suggesting coordination or data transfer between networks for past and future memories.

This implies that the quality of sleep between learning events may impact not only how well we retain what we’ve already learned, but also how effectively we will absorb new information in the near future.

While more research is needed, these findings could provide valuable insights for education, memory disorder treatments, and enhancing cognitive performance.

“Inokuchi states, ‘We believe that altering brain activity during sleep or modifying sleep patterns could reveal ways to boost memory by unlocking the brain’s hidden potential.'”

Inokuchi explains, “Sleep is more than rest—it’s crucial for how the brain processes information. We hope people will value sleep more and use it to improve their quality of life.”

Read the original article on: Sciencealert

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