Wearable Device Eases Pain and Depression in 40 Minutes

A head-mounted ultrasound device has recently undergone two human trials, demonstrating its potential to alleviate pain and depression effectively.

The device, named the Diadem, was developed by researchers at the University of Utah and resembles an elaborate headphone band. It employs neuromodulation, using ultrasonic waves to target specific brain areas. For these trials, it focused on the anterior cingulate cortex, known for its role in pain perception and emotional regulation.

In the pain study, 20 chronic pain sufferers received two sessions with the Diadem, following a functional MRI scan to pinpoint the pain-signaling brain regions.

Results showed that 60% of participants experienced at least a 33% reduction in pain immediately after treatment. In another trial involving 14 clinically depressed individuals, 10 reported remission just one week after a single session with the device.

Researchers Applaud Significant Improvements

Tom Riis, the lead author and a postdoctoral researcher in Biomedical Engineering, expressed his amazement at the results. “After only a single 40-minute session, patients are showing significant improvements in symptoms,” he said. Although not every participant saw drastic changes, those who did exhibited remarkable transformations in mood and behavior.

Diadem’s non-invasive approach represents a significant advancement in brain stimulation techniques.

Unlike other methods that require implanting devices or electrodes, Diadem manages to overcome the challenge of the skull’s thickness, which often disrupts signal precision. By adjusting for the scattering effects of bone, Diadem achieves millimeter-level accuracy in targeting specific brain regions.

Preparation for Phase 3 Trials and Public Availability

Riis and his team are preparing for Phase 3 clinical trials, aiming for FDA approval to make Diadem available to the public.

Professor Jan Kabanek, a co-author of the study, highlighted the promising potential of this technology for patients unresponsive to current treatments. Chronic pain sufferers interested in participating in the trials can contact the team at [email protected].

Kubanek concluded, “The potential for this technique to transform or even save lives is becoming more evident. We urge individuals with these conditions to join our study and help us make this promising treatment widely accessible as soon as possible.”

Read the Original Article: New Atlas

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