Tag: Cognitive Decline

  • Scientists Evaluated AI for Detecting Cognitive Decline. The Findings Were Surprising

    Scientists Evaluated AI for Detecting Cognitive Decline. The Findings Were Surprising

    It’s been just under two years since OpenAI introduced ChatGPT to the public, allowing anyone online to collaborate with an AI on tasks ranging from poetry and schoolwork to drafting letters for their landlord.
    Credit: Pixabay

    It’s been just under two years since OpenAI introduced ChatGPT to the public, allowing anyone online to collaborate with an AI on tasks ranging from poetry and schoolwork to drafting letters for their landlord.

    Today, ChatGPT is just one of several advanced large language models (LLMs) capable of responding to basic queries in a way that feels remarkably human.

    However, researchers in Israel have discovered that this human-like quality may go further than intended—finding that LLMs experience a form of cognitive decline that worsens over time, much like the aging human brain.

    The team tested publicly available chatbots, including ChatGPT versions 4 and 4o, two iterations of Alphabet’s Gemini, and version 3.5 of Anthropic’s Claude, using a series of cognitive assessments.

    If these models were truly intelligent, the results would be alarming.

    Researchers Identify Cognitive Decline in AI Models, Drawing Parallels to Human Neurodegeneration

    In their published study, neurologists Roy Dayan and Benjamin Uliel from Hadassah Medical Center, along with data scientist Gal Koplewitz from Tel Aviv University, describe a level of cognitive deterioration comparable to neurodegenerative processes in the human brain.

    Despite their conversational fluency, LLMs function more like predictive text systems than biological brains that actively generate knowledge. While their statistical approach enables rapid and personable responses, it also makes them highly susceptible to misinformation—struggling to distinguish fact from fiction.

    To be fair, human cognition isn’t flawless either. But as AI takes on increasingly critical roles, from medical guidance to legal advice, expectations have risen that each new generation of LLMs will become better at reasoning about the information they generate.

    To evaluate the gap between current AI capabilities and human cognition, the researchers subjected these models to a battery of tests, including the Montreal Cognitive Assessment (MoCA)—a tool commonly used by neurologists to assess memory, spatial awareness, and executive function.

    AI Cognitive Assessment Reveals Varying Levels of Impairment Across Models

    ChatGPT 4o achieved the highest score on the assessment, earning 26 out of 30 points, which falls within the range of mild cognitive impairment. ChatGPT 4 and Claude followed closely with 25 points, while Gemini lagged significantly behind with just 16 points—a score that, in humans, would indicate severe impairment.

    Comparisons of five LLM MoCA scores. (Dayan et al., BMJ, 2025)

    A closer look at the results reveals that all models struggled with visuospatial and executive function tasks.

    Tasks such as trail-making, replicating a simple cube design, and drawing a clock proved especially challenging for the LLMs, with most either failing outright or requiring detailed instructions to complete them.

    Attempts to draw a Necker cube (top left) by a human (top right) and ChatGPT versions 4 (bottom left) and 4o (bottom right). (Dayan et al., BMJ, 2025)

    AI Models Display Dementia-Like Responses in Spatial Awareness Tests

    Some responses regarding spatial awareness resembled those given by dementia patients. For example, Claude answered, the specific place and city would depend on where you, the user, are located at the moment.”

    Similarly, all models displayed a lack of empathy in a section of the Boston Diagnostic Aphasia Examination, a trait often linked to frontotemporal dementia.

    As expected, older LLM versions performed worse than newer ones, suggesting that each generation improves upon the cognitive limitations of its predecessors.

    The researchers acknowledge that LLMs are not human brains, making it impossible to diagnose them with dementia. However, their findings challenge the assumption that AI is on the brink of revolutionizing clinical medicine, a field that often depends on interpreting complex visual information.

    With AI development progressing rapidly, a future LLM may eventually achieve perfect scores on cognitive assessments. Until then, even the most advanced models should be approached with caution when offering advice.


    Read the original article on: Science Alert

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  • Scientists Suggest that Adhering to this Diet may Help Slow Cognitive Decline

    Scientists Suggest that Adhering to this Diet may Help Slow Cognitive Decline

    A study published in Neurology, the journal of the American Academy of Neurology, suggests that individuals whose diets closely follow the MIND diet may have a lower risk of cognitive decline. This association was observed in both Black and white participants. However, the findings show a correlation rather than proving that the MIND diet directly prevents cognitive impairment.
    A study published in Neurology suggests that closely following the MIND diet may lower the risk of cognitive impairment, with a stronger effect observed in women and Black participants. While the study shows an association between the diet and reduced risk, it does not prove causation. Credit: Pixabay

    A study published in Neurology, the journal of the American Academy of Neurology, suggests that individuals whose diets closely follow the MIND diet may have a lower risk of cognitive decline. This association was observed in both Black and white participants. However, the findings show a correlation rather than proving that the MIND diet directly prevents cognitive impairment.

    The MIND diet combines elements of the Mediterranean and DASH diets, emphasizing leafy green vegetables like spinach, kale, and collard greens, alongside other vegetables. It also recommends whole grains, olive oil, poultry, fish, beans, nuts, and prioritizes berries over other fruits. The diet suggests consuming at least one serving of fish per week.

    With dementia rates rising as the population ages, it’s vital to identify changes that can delay or slow the onset of cognitive decline,” said study author Dr. Russell P. Sawyer of the University of Cincinnati in Ohio and a member of the American Academy of Neurology.

    We were particularly interested in whether diet influences the risk of cognitive impairment in both Black and white participants.”

    The study followed 14,145 participants with an average age of 64, of which 70% were white and 30% were Black, over an average period of 10 years.

    Assessing Diets Based on the MIND Diet Guidelines

    Participants completed a questionnaire about their diet over the past year, and researchers assessed how closely their food intake aligned with the MIND diet. Points were awarded for specific dietary habits, including: three or more daily servings of whole grains, six or more weekly servings of green leafy vegetables, one or more daily servings of other vegetables, two or more weekly servings of berries, one or more weekly servings of fish, two or more weekly servings of poultry, three weekly servings of beans, five daily servings of nuts, four or fewer weekly servings of red meat, one or fewer weekly servings of fast or fried foods, one or more weekly servings of olive oil, one or fewer tablespoons of butter or margarine daily, five or fewer weekly servings of pastries and sweets, and one daily glass of wine. The maximum score was 12.

    Researchers divided participants into three groups based on their diet scores: the low group had an average score of five, the middle group had an average score of seven, and the high group averaged nine.

    Cognitive Impairment Rates Across Diet Groups

    Participants’ thinking and memory skills were assessed at the start and end of the study. Cognitive impairment occurred in 532 people, or 12%, out of 4,456 in the low diet group; 617 people, or 11%, out of 5,602 in the middle group; and 402 people, or 10%, out of 4,086 in the high group.

    After adjusting for factors like age, high blood pressure, and diabetes, researchers found that individuals in the high group had a 4% lower risk of cognitive impairment compared to those in the low group.

    When analyzing gender differences, researchers found a 6% reduced risk for cognitive impairment in women who followed the diet closely, but no significant decrease for men.

    They also examined the rate at which participants’ cognitive skills declined. Those who adhered more closely to the MIND diet experienced slower cognitive decline, with a stronger effect observed in Black participants compared to white participants.

    These findings call for further research, particularly to explore the differing impacts among men, women, and Black and white individuals. It’s promising to think that simple dietary changes could reduce or delay cognitive issues,” said Sawyer.

    A limitation of the study was its focus on older Black and white participants, so the results may not apply to other populations.


    Read the original article on: Scitech Daily

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  • Probiotics and Cognitive Decline: Addressing Aging’s Effects on the Brain

    Probiotics and Cognitive Decline: Addressing Aging’s Effects on the Brain

    A recent study indicates that probiotics may improve cognitive function and potentially prevent age-related cognitive decline by modulating the gut microbiome. Particularly in individuals with mild cognitive impairment, shifts in gut microbiome composition, such as decreases in the abundance of Prevotella bacteria, correlated with improved cognitive scores
    A recent study indicates that probiotics may improve cognitive function and potentially prevent age-related cognitive decline by modulating the gut microbiome. Particularly in individuals with mild cognitive impairment, shifts in gut microbiome composition, such as decreases in the abundance of Prevotella bacteria, correlated with improved cognitive scores. Credit: Pixaobay

    Recent research highlights the gut’s crucial role in maintaining brain health. The study’s results suggest that using a probiotic could potentially mitigate memory and cognitive decline associated with aging. This breakthrough may pave the way for innovative, non-invasive approaches leveraging the gut microbiome to combat cognitive deterioration in the elderly.

    During the study, participants with mild cognitive impairment experienced an improvement in cognitive scores after a three-month intake of the probiotic Lactobacillus rhamnosus GG (LGG). This cognitive enhancement was linked to changes in their gut microbiome.

    Microbiology Doctoral Candidate’s Enthusiasm for Cognitive Health

    In fact, Mashael Aljumaah, a microbiology doctoral candidate at the University of North Carolina at Chapel Hill and North Carolina State University, expressed excitement over the finding, seeing it as an opportunity to boost cognitive performance in individuals with mild cognitive impairment through gut microbiome modification using probiotics. This discovery enriches our understanding of the brain-gut connection and opens up potential avenues for addressing age-related cognitive decline.

    Aljumaah, also affiliated with King Saud University in Saudi Arabia, presented the research at NUTRITION 2023, the annual flagship meeting of the American Society for Nutrition held in Boston from July 22 to 25.

    Unlike many studies that concentrate on advanced cognitive diseases like Alzheimer’s and dementia, this research specifically targets mild cognitive impairment, offering a chance to slow down or prevent progression to more severe cognitive conditions at an earlier stage.

    Graphical abstract. Credit: Mashael Aljumaah, University of North Carolina at Chapel Hill and North Carolina State University

    Investigating Probiotic Impact on Cognitive Health

    However, the study comprised 169 participants aged between 52 and 75 years, categorized into two groups based on their neurological condition: those with no neurological issues and those with mild cognitive impairment. Each group underwent a double-blind, randomized clinical trial lasting three months, during which they received either the LGG probiotic or a placebo. The choice of the LGG probiotic was based on its potential benefits observed in animal models in prior research.

    To assess the participants’ gut microbiomes, the researchers utilized 16S rRNA gene sequencing to identify and compare the bacteria present in their stool samples. Additionally, whole genome sequencing provided insights into the functional roles of the identified bacteria.

    Prevotella Abundance and Early Cognitive Impairment Detection

    The analysis unveiled a higher relative abundance of microbes in the genus Prevotella among participants with mild cognitive impairment compared to those without cognitive issues. This finding suggests that gut microbiome composition might serve as an early indicator for mild cognitive impairment, presenting opportunities for early interventions to potentially slow down cognitive decline.

    Participants with mild cognitive impairment who received LGG probiotics experienced a decrease in the relative abundance of Prevotella. This change was associated with improved cognitive scores, indicating the potential to enhance cognitive health in older adults through manipulation of the gut microbiota.

    Aljumaah’s Perspective

    Mashael Aljumaah emphasized the groundbreaking nature of identifying specific shifts in the gut microbiome linked to mild cognitive impairment, offering promising avenues for preventive strategies in cognitive health. If these findings are corroborated in future studies, targeting the gut microbiome could become a novel approach to support cognitive well-being.

    To conclude, the researchers are currently investigating the precise mechanisms through which microbes like Prevotella influence the gut, leading to improved brain health. In particular, they are exploring how certain molecules produced by these bacteria modulate neuroprotective hormones’ functionality, enabling them to cross the blood-brain barrier.

    Reference: “The Gut Microbiome, Mild Cognitive Impairment, and Probiotics: a Randomized Clinical Trial in Middle-Aged and Older Adults” by Mashael R. Aljumaah, Andrea M. Azcarate-Peril, Jeffery Roach, John Gunstad, and Urja Bhatia, presented at NUTRITION 2023 on July 24, 2023. (Abstract and presentation details).


    Read the original article on Scitech Daily.

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