credit: pixabay For the first time, researchers have successfully engineered a mouse with a completely functional human immune system and a human-like gut microbiome. Consequently, this groundbreaking 'humanized' mouse model eliminates much of the uncertainty in medical research and, furthermore, has the potential to revolutionize drug testing and the understanding of disease mechanisms. Achievement in Genetic...
Dental professionals should be aware that the majority of systemic conditions often show symptoms in the mouth. These conditions include autoimmune disorders like Sjögren's syndrome, lupus, sarcoidosis, diabetes, HIV, and hematological issues. In some cases, oral symptoms of conditions such as Crohn's disease can appear before gastrointestinal symptoms. As a dental professional, I have...
Credit: CC0 Public Domain A group of scientists at Korea Advanced Institute of Science and Technology, collaborating with an associate from Myunggok Medical Research Center, has found that test mice deliberately overfed to make them obese put up a more robust immune reaction against the herpes simplex virus two than did mice fed usually. In their...
A 3-dimensional model of a natural killer cell (purple) with granules (yellow) attaching to a target cell (gray). A pseudo color scale shows differences in packing density of lipids on NK cell membrane, with warmer colors indicating higher density. Credit: Orange lab, CUIMC A recently uncovered fat 'guard' that avoids natural killer cells from being...
The darker areas are killer T cells that invaded the mouse's pancreas and attacked beta cells that produce insulin. The peptide MOTS-c treatment on the right decreased the amount of killer T cells, delaying the onset of type 1 diabetes. Credit: University of Southern California According to recent research in live mice and human cells...
The continuing development of new SARS-CoV-2 mutations allows the virus to spread more effectively and also avert antibodies. However, it is unclear whether brand-new strains can escape T-cell immunity - one of the body's main lines of protection against COVID-19. The development of a T-cell immune reaction is significantly governed by genetic factors, consisting of...
UK researchers at the University of Exeter have identified an unprecedented genetic mutation present in two siblings, unseen in any other individuals. This finding opens avenues for novel treatment strategies in the realm of type 1 diabetes. The mutation occurs within the gene responsible for encoding programmed death-ligand 1 (PD-L1) protein. A recent study elucidates...
Credit: Depositphotos Alzheimer's and Reduced Cancer Risk: Unveiling a Mysterious Link Research has revealed that individuals with Alzheimer's disease appear to have a lower risk of developing certain cancers, and a recent study involving rodents may provide insight into this phenomenon. In a study conducted in China, scientists observed that mice exhibiting Alzheimer-like symptoms had a notably...
Credit: Depositphotos Did you know that the bananas we eat now differ from those consumed a few generations ago? Today's common banana is the Cavendish variety, while the Gros Michel variety, which was widely available until the 1950s, was decimated by a disease known as Fusarium wilt of banana (FWB). The Fusarium wilt that devastated the...
Credit: Depositphotos Doctors announced on Thursday that a 60-year-old German man may be the seventh person effectively cured of HIV after undergoing a stem cell transplant. This difficult and risky procedure is reserved for individuals with both HIV and aggressive leukemia, making it unsuitable for the vast majority of the nearly 40 million people living...
